Low-Dose Colchicine May Help Stabilize Coronary Plaques

Jun 10, 2025

June 09, 2025

The LoDoCo2 trial found a reduced cardiovascular risk with low-dose colchicine in patients with chronic coronary disease. In this substudy, attenuation of pericoronary adipose tissue did not differ between patients receiving low-dose colchicine and those receiving placebo; however, people taking colchicine had a higher volume of dense calcified plaque, indicating improved plaque stability.

Low-dose colchicine was associated with an overall higher volume of calcified plaque, particularly dense calcified plaque, as well as a lower burden of low-attenuation plaque in participants treated

with colchicine and low-intensity statins,” the researchers wrote. “Although the cross-sectional design of the study limits causal inference, these are features of plaque stability and may partly explain the reduction in risk of cardiovascular events associated with colchicine in patients with chronic coronary disease.”

This study was led by Aernoud T L Fiolet, MD, PhD, of University Medical Centre Utrecht, Utrecht, the Netherlands. It was published online on May 19, 2025, in Heart.

The researchers conducted this cross-sectional analysis at the end of treatment, without any baseline or temporal studies. This study had relatively fewer women than the proportion of women with cardiovascular disease in the general population. Additional imaging modalities were not used to confirm the findings from CCTA.

This study received grants from the Australian National Institutes of Health/National Heart, Lung, and Blood Institute, Withering Stichting Nederland, the Netherlands Heart Foundation, and the Netherlands Organisation for Health Research and Development. One author reported receiving software royalties from Cedars-Sinai Medical Center. Another author reported giving presentations, and three authors reported serving as consultants for pharmaceutical and healthcare companies without receiving any personal fees.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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